Review of therapy response and survival of patients with glioma or glioblastoma and IDH mutation

Academic Paper from the year 2018 in the subject Medicine - Pathology, grade: 85%, University of Southampton, language: English, abstract: Gliomas are the most common type of human brain cancers and make up a third of all tumours of the central nervous system. Mutations in the IDH-gene are frequent and regarded as an early event in gliomagenesis. IDH mutations are considered to be associated with better outcome. If this accounts for all histological subtypes and for low as well as for high grade gliomas has yet to be clarified. The aim of this paper is to present recent evidence on the question of whether mutations of the IDH-gene affect the outcome of patients with glioma/glioblastoma. For this, electronic databases were searched for studies published after 2008, which yielded 1160 articles. The quality of the studies was critically evaluated. Overall Survival, Progression Free Survival and their p-values were analysed to assess the relation between IDH mutation and outcome. The results were extracted, analysed and compared to gain a thorough overview of the current evidence base.